Deciphering the Role of Protein Kinase D1 (PKD1) in Cellular Proliferation.
Ilige YoussefJean-Marc RicortPublished in: Molecular cancer research : MCR (2019)
Protein kinase D1 (PKD1) is a serine/threonine kinase that belongs to the calcium/calmodulin-dependent kinase family, and is involved in multiple mechanisms implicated in tumor progression such as cell motility, invasion, proliferation, protein transport, and apoptosis. While it is expressed in most tissues in the normal state, PKD1 expression may increase or decrease during tumorigenesis, and its role in proliferation is context-dependent and poorly understood. In this review, we present and discuss the current landscape of studies investigating the role of PKD1 in the proliferation of both cancerous and normal cells. Indeed, as a potential therapeutic target, deciphering whether PKD1 exerts a pro- or antiproliferative effect, and under what conditions, is of paramount importance.
Keyphrases
- protein kinase
- polycystic kidney disease
- signaling pathway
- cell cycle arrest
- poor prognosis
- induced apoptosis
- single cell
- gene expression
- pi k akt
- staphylococcus aureus
- binding protein
- stem cells
- escherichia coli
- long non coding rna
- cell migration
- small molecule
- tyrosine kinase
- amino acid
- climate change
- case control
- candida albicans