Widespread expression of Sonic hedgehog (Shh) and Nrf2 in patients treated with cisplatin predicts outcome in resected tumors and are potential therapeutic targets for HPV-negative head and neck cancer.

Abu Shadat M NomanRashed R ParagMuhammad I RashidMohammad Z RahmanAli A ChowdhuryAfrin SultanaChandsultana JerinAyesha SiddiquaLutfur RahmanAfsana ShirinJunayed NayeemReaz MahmudSonam AktherRajib K ShilIkram HossainSharmin AlamArfina ChowdhuryShabnam B BasherAbul HasanShammy BithyJannatul AklimaMizanur RahmanNabila ChowdhuryTahmina BanuBedri KarakasHerman YegerWalid A FarhatSyed S Islam

Published in: Therapeutic advances in medical oncology (2020)

These findings suggest that Shh and Nrf2 could serve as therapeutic targets as well as promising dual prognostic therapeutic biomarkers for HNSCC.

Keyphrases

climate change
oxidative stress
poor prognosis
high grade
lymph node
binding protein
prognostic factors
risk assessment