Pharmacological inhibition of STING reduces neuroinflammation-mediated damage post-traumatic brain injury.
Amelia L FryerAmar AbdullahFrank MobilioAndrew I JoblingZachery MooreMichael de VeerGang ZhengBruce X WongJuliet M TaylorPeter J CrackPublished in: British journal of pharmacology (2024)
This study demonstrates the neuroprotective activity of C-176 in ameliorating acute neuroinflammation and preventing white matter neurodegeneration post-TBI. This study highlights the therapeutic potential of small-molecule inhibitors targeting STING for the treatment of trauma-induced inflammation and neuroprotective potential.
Keyphrases
- traumatic brain injury
- small molecule
- cerebral ischemia
- white matter
- oxidative stress
- liver failure
- severe traumatic brain injury
- multiple sclerosis
- lps induced
- high glucose
- subarachnoid hemorrhage
- human health
- drug delivery
- climate change
- hepatitis b virus
- cancer therapy
- extracorporeal membrane oxygenation
- protein protein
- smoking cessation
- aortic dissection
- mild traumatic brain injury