Oncolytic adenovirus and gene therapy with EphA2-BiTE for the treatment of pediatric high-grade gliomas.

Claudia Manuela ArnoneVinicia Assunta PolitoAngela MastronuzziAndrea CaraiFrancesca Camassei DiomediLaura AntonucciLucia Lisa PetrilliMaria VinciFrancesco FerrariElisa SalviatoMarco ScarsellaCristiano De StefanisGerrit Weber Concetta QuintarelliBiagio De AngelisMalcolm K BrennerStephen Gottschalk Valentina HoyosFranco LocatelliIgnazio Caruana Francesca Del Bufalo

Published in: Journal for immunotherapy of cancer (2022)

The combination of OA and EphA2-BiTE gene therapy strongly enhances the antitumor activity of OA, inducing the eradication of highly resistant tumor cells, thus supporting the clinical translation of the approach.

Keyphrases

gene therapy
high grade
low grade
knee osteoarthritis
helicobacter pylori infection
young adults
combination therapy
replacement therapy