Grip Strength in Patients with Gastrointestinal Diseases.

We sought to elucidate factors contributing to the grip strength (GS) decline in patients with gastrointestinal diseases (Ga-Ds, n = 602, 379 males, median age = 72 years). The GS decline in males and females was defined as <28 kg and <18 kg, respectively, following the current Asian guidelines. The median GS (male) was 28.8 kg, and GS decline (male) was found in 169 patients (44.6%). The median GS (female) was 17.5 kg, and GS decline (female) was found in 122 patients (54.7%). Advanced cancer was identified in 145 patients (24.1%). In terms of the univariate analysis of parameters of the GS decline, age ( p < 0.0001), gender ( p = 0.0181), body mass index (BMI, p = 0.0002), ECOG-PS ( p < 0.0001), SARC-F score ( p < 0.0001), hemoglobin value ( p < 0.0001), total lymphocyte count ( p < 0.0001), serum albumin value ( p < 0.0001), C reactive protein (CRP) value ( p < 0.0001), and estimated glomerular filtration rate were statistically significant. In terms of the multivariate analysis, age ( p < 0.0001), BMI ( p = 0.0223), hemoglobin value ( p = 0.0186), serum albumin value ( p = 0.0284), the SARC-F score ( p = 0.0003), and CRP value ( p < 0.0001) were independent parameters. In conclusion, the GS decline in patients with Ga-Ds is closely associated with not only the primary factor (i.e., aging) but also secondary factors such as inflammatory factors and nutritional factors.