The PPARα/CYP4A14 bile acid pathway is associated with lipid metabolism disorders caused by low birth weight with high-fat diet.

Fei ZhouLinquan YangWenwen SunXing WangNa GuoHuijuan MaLinlin Yang

Published in: Food & nutrition research (2023)

LBW mice are more prone to dyslipidemia probably due to downregulated bile acid metabolism-related PPARα/CYP4A14 pathway, resulting in insufficient metabolism of cholesterol to bile acids, which, in turn, leads to elevated blood cholesterol.

Keyphrases

high fat diet
low birth weight
insulin resistance
preterm infants
high fat diet induced
adipose tissue
human milk
preterm birth
low density lipoprotein
fatty acid
metabolic syndrome
skeletal muscle
type diabetes
sensitive detection
living cells
fluorescent probe
single molecule