The trace elements can cause the initiation and the progression of the tumorous growth, which is expressed in the increased proliferation of tumor cells. This leads to the destabilization of the genetic material which can be expressed in the synthesis of mutant p53 protein. Finally, it leads to the block of apoptosis and regulatory effects of cells. This can cause the tumor progression and the destabilization of the genome, which is reflected in the increased DNA fragmentation.
Keyphrases
- cell cycle arrest
- heavy metals
- induced apoptosis
- endoplasmic reticulum stress
- cell death
- genome wide
- oxidative stress
- signaling pathway
- pi k akt
- poor prognosis
- risk assessment
- circulating tumor
- transcription factor
- health risk
- single molecule
- health risk assessment
- protein protein
- human health
- gene expression
- sewage sludge
- wild type
- climate change