TREM-1 Is Upregulated in Experimental Periodontitis, and Its Blockade Inhibits IL-17A and RANKL Expression and Suppresses Bone loss.

Nagihan BostanciToshiharu AbeGeorgios N Belibasakis George Hajishengallis

Published in: Journal of clinical medicine (2019)

Our findings show for the first time that TREM-1 regulates the IL-17A-RANKL/OPG axis and bone loss in experimental periodontitis, and its therapeutic blockade may pave the way to a novel treatment for human periodontitis.

Keyphrases

bone loss
endothelial cells
poor prognosis
induced pluripotent stem cells
binding protein
inflammatory response
toll like receptor
replacement therapy