MR-guided focused ultrasound liquid biopsy enriches circulating biomarkers in patients with brain tumors.

Ying MengChristopher B PopleSuganth SuppiahMaheleth LlinasYuexi HuangArjun SahgalJames PerryJulia KeithBenjamin DavidsonClement HamaniYutaka AmemiyaArun SethHon LeongChinthaka C HeynIsabelle AubertKullervo HynynenNir Lipsman

Published in: Neuro-oncology (2021)

This first-in-human proof-of-concept study shows MRgFUS enriches the signal of circulating brain-derived biomarkers, demonstrating the potential of the technology to support liquid biopsy for the brain.

Keyphrases

resting state
white matter
ultrasound guided
endothelial cells
fine needle aspiration
ionic liquid
functional connectivity
magnetic resonance
magnetic resonance imaging
pluripotent stem cells
computed tomography
multiple sclerosis
risk assessment
blood brain barrier