Role of Systemic Lupus Erythematosus Risk Variants With Opposing Functional Effects as a Driver of Hypomorphic Expression of TNIP1 and Other Genes Within a Three-Dimensional Chromatin Network.

Satish PasulaKandice L TessneerYao FuJaanam GopalakrishnanRichard C PelikanJennifer A KellyGraham B WileyMandi M WileyPatrick M Gaffney

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

Hypomorphic TNIP1 expression results from the combined concordant and opposing effects of multiple risk variants carried on the TNIP1 risk haplotype, with the strongest regulatory effect in B lymphoid lineage cells. Furthermore, the TNIP1 risk haplotype effect extends to neighboring genes within a shared chromatin network.

Keyphrases

systemic lupus erythematosus
poor prognosis
transcription factor
gene expression
rheumatoid arthritis
dna methylation
cell death
copy number
binding protein
long non coding rna
cell cycle arrest
genome wide identification