Ultrasound-assisted catheter-directed thrombolysis versus surgical pulmonary embolectomy for intermediate-high or high-risk pulmonary embolism: a randomized phase II non-inferiority trial.
Stefan StorteckyAlexandru GrigoreanStephan WindeckerDik HegAlexander KadnerLars EnglbergerNils KucherPublished in: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2024)
In patients with intermediate-high and high-risk acute PE, USAT was not non-inferior when compared with SPE in reducing RV/LV ratio within the first 72 h. In a post hoc superiority analysis, SPE resulted in greater improvement of RV overload and reduction of thrombus burden.
Keyphrases
- pulmonary embolism
- phase ii
- clinical trial
- mycobacterium tuberculosis
- open label
- inferior vena cava
- ms ms
- phase iii
- pulmonary hypertension
- liver failure
- placebo controlled
- solid phase extraction
- double blind
- study protocol
- randomized controlled trial
- risk factors
- respiratory failure
- high resolution
- ultrasound guided
- intensive care unit
- acute ischemic stroke
- tandem mass spectrometry