HRCT1, negatively regulated by miR-124-3p, promotes tumor metastasis and the growth of gastric cancer by activating the ERBB2-MAPK pathway.

Feng HouDuan-Bo ShiXiang-Yu GuoRui-Nan ZhaoHui ZhangRan-Ran MaJun-Yi HePeng Gao

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2023)

The upregulated expression of HRCT1 predicts poor survival for patients with gastric cancer. HRCT1 promotes tumor progression by activating the ERBB2-MAPK pathway. HRCT1, negatively regulated by miR-124-3p, may be a potential therapeutic target for patients with gastric cancer.

Keyphrases

signaling pathway
poor prognosis
pi k akt
oxidative stress
tyrosine kinase
cell proliferation
binding protein
human health