We report temporal changes in 18 F-FDG PET/CT in neuronal intranuclear inclusion disease (NIID). In a patient with encephalitis-like episodes, PET showed hypermetabolism correlating with EEG alterations. Affected sites later became hypometabolic and showed diffusion changes on MRI. In another patient, hypermetabolic regions correlated well with the EEG, whereas MRI showed changes after only 1 month. One chronic patient had diffuse hypometabolism, which correlated with atrophy on MRI and cerebral dysfunction on EEG. This is the first report of temporal changes in PET in NIID and suggests that it reflects the disease activity of NIID while correlating well with EEG.
Keyphrases
- disease activity
- functional connectivity
- resting state
- working memory
- case report
- contrast enhanced
- magnetic resonance imaging
- rheumatoid arthritis
- systemic lupus erythematosus
- computed tomography
- diffusion weighted imaging
- ankylosing spondylitis
- positron emission tomography
- rheumatoid arthritis patients
- pet ct
- oxidative stress
- subarachnoid hemorrhage
- juvenile idiopathic arthritis
- low grade
- high density
- high grade
- drug induced