Blood Neutrophils In COPD But Not Asthma Exhibit A Primed Phenotype With Downregulated CD62L Expression.

Ravi Lokwani Peter A B WarkKatherine J BainesMichael Fricker Daniel Barker Jodie Louise Simpson

Published in: International journal of chronic obstructive pulmonary disease (2019)

Reduced CD62L expression suggests blood neutrophils have undergone priming in COPD but not in asthma, which may be the result of systemic inflammation. The increased shedding of CD62L receptor by COPD blood neutrophils suggests a high sensitivity for activation.

Keyphrases

chronic obstructive pulmonary disease
lung function
poor prognosis
cystic fibrosis
air pollution
nk cells
binding protein
long non coding rna