Optimization of atorvastatin and quercetin-loaded solid lipid nanoparticles using Box-Behnken design.
Dimple S LalchandaniLaltanpuii ChenkualKailas SonpasareBishal RajdevVgm NaiduNaveen ChellaPawan Kumar PorwalPublished in: Nanomedicine (London, England) (2024)
Aim: The study explores the synergistic potential of atorvastatin (ATR) and quercetin (QUER)- loaded solid lipid nanoparticles (SLN) in combating breast cancer. Materials & methods: SLNs were synthesized using a high-shear homogenization method and optimized using Box-Behnken design. The SLNs were characterized and evaluated for their in vitro anticancer activity. Results: The optimized SLN exhibited narrow size distribution (PDI = 0.338 ± 0.034), a particle size of 72.5 ± 6.5 nm, higher entrapment efficiency (<90%), sustained release and spherical surface particles. The in vitro cytotoxicity studies showed a significant reduction in IC 50 values on MDA-MB-231 cell lines. Conclusion: We report a novel strategy of repurposing well-known drugs and encapsulating them into SLNs as a promising drug-delivery system against breast cancer.
Keyphrases
- cancer therapy
- drug delivery
- transcription factor
- binding protein
- fatty acid
- photodynamic therapy
- wound healing
- squamous cell carcinoma
- breast cancer cells
- radiation therapy
- cell proliferation
- walled carbon nanotubes
- lymph node
- case control
- young adults
- risk assessment
- human health
- breast cancer risk
- rectal cancer
- cell cycle arrest