Finding predictors for successful opioid response in cancer patients: An analysis of data from four randomized controlled trials.

Maike S ImkampMaurice Theunissen Justin G L M LuermansJohan HaumannOscar CorliCristina BosettiWojciech LeppertCinzia BrunelliErnesto ZeccaMarieke Henrica Johanna Van den Beuken-Van Everdingen

Published in: Pain practice : the official journal of World Institute of Pain (2023)

Fentanyl and methadone, and mixed pain were found to be statistically significant predictors of treatment success in patients with cancer-related pain. With the predictors currently assessed our data did not allow for the creation of a clinical prediction model with good discriminative power. Additional - unrevealed - predictors are necessary to develop a future prediction model.

Keyphrases

chronic pain
pain management
randomized controlled trial
electronic health record
neuropathic pain
big data
clinical trial
machine learning
combination therapy
smoking cessation
replacement therapy