Late sodium current inhibitors to treat exercise-induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium.

Cecilia FerrantiniJosè Manuel PionerLuca MazzoniFrancesca GentileBenedetta TosiAlessandra RossiLuiz BelardinelliChiara TesiChiara PalandriRosanna MatucciElisabetta CerbaiIacopo OlivottoCorrado PoggesiAlessandro MugelliRaffaele Coppini

Published in: British journal of pharmacology (2018)

Ranolazine and GS-967 reduced septal myocardium tension during simulated exercise in vitro and therefore have the potential to ameliorate symptoms caused by inducible obstruction in HCM patients, with some advantages over disopyramide and β-blockers.

Keyphrases

hypertrophic cardiomyopathy
left ventricular
endothelial cells
high intensity
induced pluripotent stem cells
pluripotent stem cells
physical activity
angiotensin converting enzyme
heart failure
sleep quality
atrial fibrillation