A SUMO4 initiator codon variant in amyotrophic lateral sclerosis reduces SUMO4 expression and alters stress granule dynamics.
Alma OsmanovicAlisa FörsterMaylin WidjajaBernd AuberAnibh M DasAnne ChristiansFrank BrandSusanne PetriRuthild G WeberPublished in: Journal of neurology (2022)
Our results are consistent with SUMO4 haploinsufficiency as a contributor to ALS pathogenesis impacting SG dynamics and possibly acting in conjunction with environmental oxidative stress-related factors.