Reappraisal of intra-abdominal candidiasis: insights from peritoneal fluid analysis.
Emmanuel NovyMathieu EspositoJulien BirckenerAdeline GermainMarie-Reine LosserMarie-Claire MachouartPhilippe GuerciPublished in: Intensive care medicine experimental (2023)
This study provides evidence of C. albicans virulence expression in the peritoneal fluid. The observed variability in virulence expression suggests that it is influenced by the composition of PF and the presence of bacterial coinfection. These findings contribute to a better understanding of the complex dynamics of intra-abdominal candidiasis and advocate for personalized approach for IAC patients. Trial registration https://clinicaltrials.gov/ (NCT05264571; February 22, 2022).
Keyphrases
- candida albicans
- poor prognosis
- biofilm formation
- escherichia coli
- end stage renal disease
- pseudomonas aeruginosa
- staphylococcus aureus
- ejection fraction
- antimicrobial resistance
- newly diagnosed
- chronic kidney disease
- clinical trial
- study protocol
- peritoneal dialysis
- binding protein
- long non coding rna
- phase iii
- patient reported outcomes