Monitoring of radiologic disease activity by serum neurofilaments in MS.
Tomas UherSabine SchaedelinBarbora SrpovaChristian BarroNiels BergslandMichael DwyerMichaela TyblovaKarolina VodehnalovaPascal BenkertJohanna OechteringDavid LeppertYvonne NaegelinJan KrasenskyManuela VaneckovaEva Kubala HavrdovaLudwig KapposRobert ZivadinovDana HorakovaJens KuhleTomas KalincikPublished in: Neurology(R) neuroimmunology & neuroinflammation (2020)
Low sNfL levels (≤30th percentile) help identify patients with MS with very low probability of recent radiologic disease activity during the preceding year. This result suggests that in future, sNfL assessment may substitute the need for annual brain MRI monitoring in considerable number (23.1%-36.4%) of visits in clinically stable patients.
Keyphrases
- disease activity
- rheumatoid arthritis
- systemic lupus erythematosus
- rheumatoid arthritis patients
- ankylosing spondylitis
- juvenile idiopathic arthritis
- end stage renal disease
- mass spectrometry
- multiple sclerosis
- ms ms
- ejection fraction
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- magnetic resonance imaging
- prognostic factors
- contrast enhanced
- white matter
- magnetic resonance
- cerebral ischemia
- diffusion weighted imaging