Beraprost sodium attenuates the development of myocardial fibrosis after myocardial infarction by regulating GSK-3β expression in rats.

Xing-Xing LiYun-Zhe WangChuang LiuGuo-Wei FuJun LiJin-Ying Zhang

Published in: Immunity, inflammation and disease (2023)

BPS treatment increased the binding of YBX1 to the GSK-3β promoter, and GSK-3β protein expression was upregulated, which further caused the upregulation of p-CREB and cAMP, and finally inhibited myocardial fibrosis.

Keyphrases

signaling pathway
pi k akt
poor prognosis
binding protein
left ventricular
cell proliferation
dna methylation
transcription factor
heart failure
long non coding rna
liver fibrosis
atrial fibrillation