In silico evaluation of a beta-lactam dosing guideline among adults with serious infections.
Paul WilliamsMenino Osbert CottaMohd Hafiz Abdul-AzizKathryn WilksAndras FarkasJason Alexander RobertsPublished in: Pharmacotherapy (2022)
Our study demonstrated that achievement of PK-PD exposures associated with an increased likelihood of effectiveness was more likely to occur with guideline-based dosing; especially at 48 h.