Integrative multiomics enhancer activity profiling identifies therapeutic vulnerabilities in cholangiocarcinoma of different etiologies.

Jinghong ChenChern Han YongHong Lee HengJason Yongsheng ChanMai Chan LauJianfeng ChenJing Yi LeeAbner Herbert LimZhimei LiPeiyong GuanPek Lim ChuArnoud BootSheng Rong NgXiaosai YaoFelicia Yu Ting WeeJeffrey Chun Tatt LimWei LiuPeili WangRong XiaoXian ZengYichen SunJoanna KohXiu Yi KwekCedric Chuan Young NgPoramate KlanritYaojun ZhangJiaming LaiDavid Wai Meng TaiChawalit PairojkulSimona DimaIrinel PopescuSen-Yung HsiehMing-Chin YuJoe Poh Sheng YeongSarinya KongpetchApinya JusakulWatcharin LoilomePatrick Boon-Ooi Tan Jing Tan Bin Tean Teh

Published in: Gut (2023)

Our study elucidates the mechanisms underlying enhancer dysregulation and deepens understanding of different tumourigenesis processes in distinct CCA subtypes, with potential significant therapeutics and clinical benefits.

Keyphrases

transcription factor
binding protein
small molecule
genome wide
single cell
gene expression
climate change
network analysis