Role of Lipopolysaccharide, Derived from Various Bacterial Species, in Pulpitis-A Systematic Review.
Aniela BrodzikowskaMonika CiechanowskaMichał KopkaAlbert StachuraPaweł K WłodarskiPublished in: Biomolecules (2022)
Lipopolysaccharide (LPS) is widely used for induction of inflammation in various human tissues, including dental pulp. The purpose of this study was to summarize current medical literature focusing on (1) cell types used by researchers to simulate dental pulp inflammation, (2) LPS variants utilized in experimental settings and how these choices affect the findings. Our study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We searched for studies reporting outcomes of lipopolysaccharide application on dental pulp cells in vitro using electronic databases: MEDLINE, Web of Science and Scopus. Having gathered data from 115 papers, we aimed to present all known effects LPS has on different cell types present in dental pulp. We focused on specific receptors and particles that are involved in molecular pathways. Our review provides an essential foundation for further research using in vitro models of pulpitis.
Keyphrases
- inflammatory response
- meta analyses
- systematic review
- toll like receptor
- oxidative stress
- lps induced
- single cell
- healthcare
- endothelial cells
- anti inflammatory
- induced apoptosis
- cell therapy
- gene expression
- big data
- randomized controlled trial
- type diabetes
- copy number
- cell cycle arrest
- dna methylation
- adipose tissue
- mesenchymal stem cells
- signaling pathway
- electronic health record
- bone marrow
- immune response
- weight loss
- pi k akt
- genome wide