Apo(a) and ApoB Interact Noncovalently Within Hepatocytes: Implications for Regulation of Lp(a) Levels by Modulation of ApoB Secretion.
Amer YoussefJustin R ClarkSantica M MarcovinaMichael B BoffaMarlys L KoschinskyPublished in: Arteriosclerosis, thrombosis, and vascular biology (2022)
Our findings explain the coupling of apo(a) and Lp(a)-apoB production observed in human metabolic studies using stable isotopes as well as the ability of agents that inhibit apoB biosynthesis to lower Lp(a) levels.