Radio-photothermal therapy is an effective modality for cancer treatment. To overcome the radio-resistance in the hypoxic microenvironment and improve the sensitivity of radiotherapy, metal nanoparticles, and radio-photothermal therapy are widely used in the research of improving the curative effect and reducing the side effects of radiotherapy. Here, we developed red blood membrane camouflaging bismuth nanoflowers (RBCM-BNF) with outstanding physiological stability and biodegradability for lung tumours. In vitro data proved that the RBCM-BNF had the greatest cancer cell-killing ability combined with X-ray irradiation and photo-thermal treatment. Meanwhile, in vivo studies revealed that RBCM-BNF can alleviate the hypoxic microenvironment and promote tumour cell apoptosis by inhibiting HIF-1α expression and increasing caspase-3 expression. Therefore, RBCM-BNF had a good radio-sensitising effect and might be a promising biomimetic nanoplatform as a therapeutic target for cancer.
Keyphrases
- poor prognosis
- early stage
- stem cells
- radiation therapy
- locally advanced
- signaling pathway
- cell proliferation
- cell death
- high resolution
- photodynamic therapy
- binding protein
- magnetic resonance imaging
- machine learning
- endothelial cells
- young adults
- cancer therapy
- single cell
- magnetic resonance
- electronic health record
- computed tomography
- drug delivery
- combination therapy
- squamous cell
- big data
- deep learning
- endoplasmic reticulum stress
- visible light
- oxide nanoparticles
- childhood cancer
- data analysis
- tissue engineering