Novel Approach Using shRNA of IQGAP1 for Colon Cancer Therapy: HCT116 as a Surrogate Model Colorectal Carcinoma

Khairy Mohamed Zoheir Khaled MahmoudGamal I HarisaAbdelkader AshourHala E Abdel-HamiedAmro A AmaraKarima F MahrousAhmed A Abd-Rabou

Published in: Asian Pacific journal of cancer prevention : APJCP (2022)

The IQGAP1 regulates the expression of IQGAPs, Ras, IL-8 receptors, and the apoptotic network. Therefore, the silence of IQGAP1 is a promising strategy for colon cancer therapy.

Keyphrases

cancer therapy
drug delivery
poor prognosis
cell death
cell cycle arrest
binding protein
wild type
cell proliferation