Metabolomic Signatures of Scarff-Bloom-Richardson (SBR) Grade in Non-Metastatic Breast Cancer.
Caroline BailleuxDavid ChardinJocelyn GalJean-Marie GuigonisSabine LindenthalFanny GraslinLaurent ArnouldAlexandre CagnardJean-Marc FerreroOlivier HumbertThierry PourcherPublished in: Cancers (2023)
This study indicates that high-grade invasive tumors are related to diacetylspermine and tryptophan metabolism, both involved in the inhibition of the immune response. Targeting these pathways could restore anti-tumor immunity and have a synergistic effect with immunotherapy. Recent studies could not demonstrate the effectiveness of this strategy, but the use of theragnostic metabolomic signatures should allow better selection of patients.
Keyphrases
- high grade
- metastatic breast cancer
- immune response
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- systematic review
- randomized controlled trial
- peritoneal dialysis
- prognostic factors
- low grade
- dendritic cells
- cancer therapy
- patient reported outcomes
- patient reported
- inflammatory response
- drug delivery