Potential Influence of Age and Diabetes Mellitus Type 1 on MSH2 (MutS homolog 2) Expression in a Rat Kidney Tissue.

Paško BabićNatalija Filipovic Lejla Ferhatović HamzićLivia PuljakKatarina VukojevićBenjamin Benzon

Published in: Genes (2022)

Age influences MSH2 expression in the kidney more than diabetes mellitus. Since ageing is a risk factor for kidney neoplasia, downregulation of MSH2 in older rats might represent one of the pro-oncogenic mechanisms of ageing at a molecular level.

Keyphrases

poor prognosis
binding protein
oxidative stress
cell proliferation
physical activity
signaling pathway
glycemic control
high grade
skeletal muscle
adipose tissue