Exploring PI3Kδ Molecular Pathways in Stable COPD and Following an Acute Exacerbation, Two Randomized Controlled Trials.
Malcolm BeggJ Nicole HamblinEmily JarvisGlyn BradleyStephen MarkDavid MichalovichMark LennonHannah E WajdnerAugustin AmourRobert WilsonKen SaundersRikako TanakaSaki AraiTeresa TangCedric Van HolsbekeJan De BackerWim VosIngrid L TitlestadJ Mark FitzGeraldKieran KillianJean BourbeauClaude PoirierFrancois MaltaisAnthony CahnEdith M HesselPublished in: International journal of chronic obstructive pulmonary disease (2021)
We provide evidence for nemiralisib-evoked changes in neutrophil migration phenotype in stable COPD but not AECOPD, despite improving lung function in the latter group. We conclude that induced sputum can be used for measuring evidence of alteration of neutrophil phenotype in stable patients, and our study provides a data set of the sputum transcriptomic changes during recovery from AECOPD.
Keyphrases
- lung function
- cystic fibrosis
- chronic obstructive pulmonary disease
- air pollution
- end stage renal disease
- mycobacterium tuberculosis
- randomized controlled trial
- drug induced
- newly diagnosed
- ejection fraction
- pulmonary tuberculosis
- chronic kidney disease
- respiratory failure
- peritoneal dialysis
- clinical trial
- single cell
- electronic health record
- high glucose
- rna seq
- systematic review
- study protocol
- artificial intelligence
- patient reported outcomes
- machine learning
- stress induced
- endothelial cells