Catalpol alleviates adriamycin-induced nephropathy by activating the SIRT1 signalling pathway in vivo and in vitro.

Jiangnan ZhangRan BiQiang MengChangyuan WangXiaokui HuoZhihao LiuChong WangPengyuan SunHuijun SunXiaodong MaJingjing WuKe-Xin Liu

Published in: British journal of pharmacology (2019)

Taken together, our results suggest that catalpol exhibits strong protective effects against adriamycin-induced nephropathy by inducing SIRT1-mediated inhibition of TRPC6 expression and enhancing MRP2 expression.

Keyphrases

poor prognosis
diabetic rats
high glucose
oxidative stress
drug induced
binding protein
ischemia reperfusion injury
signaling pathway
mouse model