Long Non-coding RNA Neat1, NLRP3 Inflammasome, and Acute Kidney Injury.

Rui XueWai Han Yiu Kam Wa ChanSarah W Y LokYixin ZouJingyuan MaHong-Yu LiLoretta Y Y ChanXiao Ru HuangKar Neng LaiHui Yao Lan Sydney Chi-Wai Tang

Published in: Journal of the American Society of Nephrology : JASN (2024)

Our findings demonstrate a pathogenic role of Neat1 induction in human and mice during AKI with alleviation of kidney injury in 3 experimental models of septic and aseptic AKI after knockdown of Neat1. LPS/TLR4-induced Neat1 overexpression in tubular epithelial cells increases the inflammatory response by binding with the scaffold protein, Rack1, to activate NLRP3 inflammasomes.

Keyphrases

acute kidney injury
inflammatory response
long non coding rna
nlrp inflammasome
cardiac surgery
poor prognosis
high glucose
endothelial cells
lipopolysaccharide induced
toll like receptor
lps induced
immune response
cell proliferation
high fat diet induced
anti inflammatory
insulin resistance
tissue engineering