Use of Population-Based Health Informatics Research to Improve Care for Patients with Cardiovascular Diseases.
Ify R MordiMagalie Guignard-DuffChristopher HallBenjamin Jaa Ming NewChim C LangPublished in: Diseases (Basel, Switzerland) (2020)
There are common clinical scenarios in chronic heart disease where no randomized controlled data exist to guide management, and it is likely that well-designed observational studies will have to be used to inform clinical practice. Showing the clinical applicability of this type of study design, using record linkage of population electronic health records, we have provided key observational evidence that use of renin-angiotensin-system (RAS) blockers is associated with better outcomes in patients with aortic stenosis and that metformin could be used safely as an antiglycemic drug in patients with diabetes and heart failure. Each of these pieces of underpinning research has made a major contribution to relevant international clinical practice guidelines, helped the Food and Drug Administration in their decision making and changed prescribing practice.
Keyphrases
- electronic health record
- healthcare
- aortic stenosis
- heart failure
- adverse drug
- primary care
- clinical practice
- decision making
- left ventricular
- ejection fraction
- cardiovascular disease
- drug administration
- transcatheter aortic valve replacement
- clinical decision support
- transcatheter aortic valve implantation
- aortic valve replacement
- aortic valve
- public health
- climate change
- open label
- palliative care
- pulmonary hypertension
- mental health
- quality improvement
- gene expression
- phase ii
- metabolic syndrome
- type diabetes
- phase iii
- health information
- randomized controlled trial
- human health
- drug induced
- hiv testing
- machine learning
- pain management
- chronic pain
- health promotion
- insulin resistance
- health insurance