Parry Romberg disease with En Coup de Sabre Scleroderma: Effect of tocilizumab on periodontal bone inflammation.
Thaís Cugler MeneghettiJuliana Yassue Barbosa da SilvaLúcio Eduardo KluppelVânia Oliveira de CarvalhoPublished in: Journal of scleroderma and related disorders (2020)
Parry Romberg disease and En Coupe de Sabre Scleroderma are frequently associated disorders that affect the face and can cause severe aesthetic and functional impairment. Systemic immunosuppression is the gold standard of first-line treatment in the pediatric rheumatology standpoint although it is often delayed in the pediatric dermatology clinics and more often used in cases of refractory neurological impairment. We report on a case with dental root resorption and severe periodontal bone inflammation detected on magnetic resonance imaging, which was successfully treated with the anti-IL-6 agent tocilizumab.
Keyphrases
- magnetic resonance imaging
- rheumatoid arthritis
- juvenile idiopathic arthritis
- systemic sclerosis
- oxidative stress
- bone mineral density
- bone loss
- interstitial lung disease
- early onset
- rheumatoid arthritis patients
- primary care
- computed tomography
- soft tissue
- bone regeneration
- disease activity
- magnetic resonance
- oral health
- body composition
- contrast enhanced
- silver nanoparticles
- breast reconstruction