Ang II (Angiotensin II)-Induced FGFR1 (Fibroblast Growth Factor Receptor 1) Activation in Tubular Epithelial Cells Promotes Hypertensive Kidney Fibrosis and Injury.

Zheng XuWu LuoLingfeng ChenZaishou ZhuangDaona YangJianchang QianZia A KhanXinfu GuanYi WangXiaokun LiGuang Liang

Published in: Hypertension (Dallas, Tex. : 1979) (2022)

Our studies uncover a novel mechanism causing renal fibrosis in hypertension and indicate FGFR1 as a potential target to preserve renal function and integrity.

Keyphrases

angiotensin ii
blood pressure
high glucose
angiotensin converting enzyme
vascular smooth muscle cells
diabetic rats
liver fibrosis
human health
risk assessment