AEG-1 as a Novel Therapeutic Target in Colon Cancer: A Study from Silencing AEG-1 in BALB/c Mice to Large Data Analysis.

Sushmitha SriramuluSarubala MalayaperumalAntara BanerjeeMuralidharan AnbalaganMakalakshmi Murali KumarRajesh Kanna Nandagopal RadhaXingyi LiuHong ZhangGuang HuXiao-Feng SunSurajit Pathak

Published in: Current gene therapy (2024)

This study revealed that AEG-1 silencing might alter EXT-1 expression indirectly through PTCH-1, influencing cell-ECM interactions, and decreasing dysplastic changes, proliferation and invasion.

Keyphrases

data analysis
single cell
poor prognosis
cell therapy
stem cells
high fat diet induced
binding protein
metabolic syndrome
extracellular matrix
skeletal muscle