Randomized Placebo Controlled Trial to Evaluate Effects of Eplerenone on Myocardial Perfusion and Function among Persons with HIV-Results from the MIRACLE HIV Study.

Suman SrinivasaAllie R WalpertTeressa S ThomasDaniel M HuckMichael Jerosch-HeroldSabeeh IslamMichael T LuTricia H BurdoChristopher R deFilippiCarolyn N DunderdaleMeghan FeldpauschSanjna IyengarGrace ShenStephen BaakMartin TorrianiGregory K RobbinsHang LeeRaymond Y KwongMarcelo DicarliGail K AdlerSteven K Grinspoon

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2023)

RAAS blockade with eplerenone benefitted key indices and prevented worsening of myocardial perfusion, injury and function among PWH with subclinical cardiac disease when compared to placebo.

Keyphrases

double blind
antiretroviral therapy
hiv positive
hiv infected
hiv testing
human immunodeficiency virus
hepatitis c virus
hiv aids
placebo controlled
phase iii
men who have sex with men
clinical trial
open label
south africa
left ventricular
randomized controlled trial
study protocol
phase ii
heart failure