Spatial transcriptomics unveils ZBTB11 as a regulator of cardiomyocyte degeneration in arrhythmogenic cardiomyopathy.
Cornelis J BoogerdGrégory P A LacrazAbel VertesySebastiaan Johannes van KampenIlaria PeriniHesther de RuiterDanielle VersteegAndreas BrodehlPetra van der KraakMauro GiaccaNicolaas de JongeJan Philipp JunkerAlexander van OudernaardenAryan VinkEva van RooijPublished in: Cardiovascular research (2022)
Our study shows the power of Tomo-Seq to unveil new molecular mechanisms in human cardiomyopathy and uncovers ZBTB11 as a novel driver of cardiomyocyte loss.