Shikonin sensitizes A549 cells to TRAIL-induced apoptosis through the JNK, STAT3 and AKT pathways.

Zhi Lan GuoJing Zhe LiYan Yan MaDan QianJu Ying ZhongMeng Meng JinPeng HuangLu Yang CheBing PanYi WangZhen Xiao SunChang Zhen Liu

Published in: BMC cell biology (2018)

In conclusion, the results indicated that shikonin sensitized resistant cancer cells to TRAIL-induced cytotoxicity via the modulation of the JNK, STAT3 and AKT pathways, the downregulation of antiapoptotic proteins and the upregulation of proapoptotic proteins.

Keyphrases

induced apoptosis
signaling pathway
cell proliferation
pi k akt
endoplasmic reticulum stress
oxidative stress
diabetic rats
high glucose
drug induced
cell cycle arrest
poor prognosis
long non coding rna
stress induced