A solid lipid particle formulation of long pepper extract reduces pain and astrocyte activation in a rat model of neuropathic pain.

Sri-Arun IamjanSiriluk VeerasakulSamur ThanoiWaree TiyaboonchaiSutisa Nudmamud-Thanoi

Published in: Journal of complementary & integrative medicine (2023)

The LPE-SLM cream has a potential effect on pain attenuation via a decrease of spinal astrocyte activation-related mechanism. The LPE in SLM preparation could provide an alternative therapeutic strategy for treating neuropathic pain.

Keyphrases

neuropathic pain
spinal cord
spinal cord injury
oxidative stress
drug delivery
chronic pain
risk assessment
fatty acid
anti inflammatory
high resolution
mass spectrometry