Imaging of chemokine receptor CXCR4 expression in culprit and nonculprit coronary atherosclerotic plaque using motion-corrected [68Ga]pentixafor PET/CT.
Thorsten DerlinDaniel G SeddingJochen DutzmannArash HaghikiaTobias KönigL Christian NappChristian SchützeNicole Owsianski-HilleHans-Jürgen WesterSaskia KropfJames T ThackerayJens P BankstahlLilli GeworskiTobias L RossJohann BauersachsFrank M BengelPublished in: European journal of nuclear medicine and molecular imaging (2018)
We demonstrated the basic feasibility of motion-corrected targeted PET/CT imaging of CXCR4 expression in coronary artery lesions, which was triggered by vessel wall inflammation but also by stent-induced injury. This novel methodology may serve as a platform for future diagnostic and therapeutic clinical studies targeting the biology of coronary atherosclerotic plaque.
Keyphrases
- pet ct
- coronary artery
- coronary artery disease
- poor prognosis
- high resolution
- pulmonary artery
- positron emission tomography
- cancer therapy
- binding protein
- oxidative stress
- high speed
- diabetic rats
- long non coding rna
- high throughput
- cell migration
- left ventricular
- atrial fibrillation
- endothelial cells
- single cell
- stress induced