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Imaging of chemokine receptor CXCR4 expression in culprit and nonculprit coronary atherosclerotic plaque using motion-corrected [68Ga]pentixafor PET/CT.

Thorsten DerlinDaniel G SeddingJochen DutzmannArash HaghikiaTobias KönigL Christian NappChristian SchützeNicole Owsianski-HilleHans-Jürgen WesterSaskia KropfJames T ThackerayJens P BankstahlLilli GeworskiTobias L RossJohann BauersachsFrank M Bengel
Published in: European journal of nuclear medicine and molecular imaging (2018)
We demonstrated the basic feasibility of motion-corrected targeted PET/CT imaging of CXCR4 expression in coronary artery lesions, which was triggered by vessel wall inflammation but also by stent-induced injury. This novel methodology may serve as a platform for future diagnostic and therapeutic clinical studies targeting the biology of coronary atherosclerotic plaque.
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