The T1-weighted/T2-weighted ratio as a biomarker of anti-NMDA receptor encephalitis.

Tim Julian HartungGraham CooperValentin JüngerDarko KomnenićLara RyanJosephine HeineClaudia ChienFriedemann PaulHarald PrüssCarsten Finke

Published in: Journal of neurology, neurosurgery, and psychiatry (2023)

The T1w/T2w ratio detects microstructural changes in grey and white matter of patients with NMDAR encephalitis that correlate with cognitive performance. Computable from conventional clinical MRI sequences, this measure shows promise in bridging the clinico-radiological dissociation in NMDAR encephalitis and could serve as an imaging outcome measure in clinical trials.

Keyphrases

white matter
contrast enhanced
clinical trial
multiple sclerosis
magnetic resonance
network analysis
high resolution
computed tomography
randomized controlled trial
diffusion weighted imaging
big data
machine learning
mass spectrometry
open label
deep learning
fluorescence imaging