TMT-based quantitative proteomics revealed follicle-stimulating hormone (FSH)-related molecular characterizations for potentially prognostic assessment and personalized treatment of FSH-positive non-functional pituitary adenomas.
Ya WangTingting ChengMiaolong LuYun MuBiao LiXuejun LiXianquan ZhanPublished in: The EPMA journal (2019)
FSH-positive expression was an important NFPA subtype. It was the first time for this study to reveal FSH-related proteomic variations and the corresponding molecular network alterations in FSH-positive relative to negative NFPAs. Also, three signaling pathways (ECM-receptor interaction, focal adhesion, and PI3K-Akt signaling pathways) and involved upregulated proteins (ITGA1, ITGA6, ITGB4, pAKT, and FSHR) were significantly associated with tumor invasiveness and aggressiveness, and a set of invasiveness-related DEPs were identified with overlapping analysis of 594 DEPs in FSH-positive vs. negative NFPAs and 898 DEGs in invasive vs. non-invasive NFPAs. These findings offered the scientific evidence to in-depth understand molecular characteristics of FSH-positive NFPAs, and effectively stratify the post-surgery patients for personalized prognostic assessment and targeted treatment of FSH-positive NFPAs.
Keyphrases
- pi k akt
- signaling pathway
- minimally invasive
- cell proliferation
- poor prognosis
- high resolution
- single molecule
- newly diagnosed
- escherichia coli
- prognostic factors
- epithelial mesenchymal transition
- drug delivery
- gene expression
- cystic fibrosis
- coronary artery bypass
- cancer therapy
- drug induced
- dna methylation
- percutaneous coronary intervention
- candida albicans