Integrative multi-omics identifies high risk multiple myeloma subgroup associated with significant DNA loss and dysregulated DNA repair and cell cycle pathways.
María Ortiz-EstévezFadi TowficErin FlyntNicholas StongIn Sock JangKai WangMatthew W B TrotterAnjan ThakurtaPublished in: BMC medical genomics (2021)
Using multi-omics unsupervised clustering we were able to discover a new high-risk multiple myeloma patient segment. This high-risk group presents diverse previously known genetic markers, but also a new characteristic defined by accumulation of genomic loss which seems to drive transcriptional dysregulation of cell cycle, DNA repair and DNA damage. Finally, our work identified various master regulators, including E2F2 and CKS1B as the genes controlling these key biological pathways.
Keyphrases
- dna repair
- cell cycle
- dna damage
- multiple myeloma
- cell proliferation
- genome wide
- single cell
- dna damage response
- oxidative stress
- transcription factor
- machine learning
- copy number
- gene expression
- rna seq
- dna methylation
- case report
- randomized controlled trial
- single molecule
- genome wide identification
- study protocol
- phase iii
- bioinformatics analysis