Effect of lipid and cellulose based matrix former on the release of highly soluble drug from extruded/spheronized, sintered and compacted pellets.

Madiha MaboosRabia Ismail YousufMuhammad Harris ShoaibIqbal NasiriTazeen HussainHafiza Fouzia AhmedWajiha Iffat

Published in: Lipids in health and disease (2018)

Extended-release encapsulated, and compacted pellets were successfully prepared after the combination of lipids CW (10%) and GMS (20%) with EC (10FP 20% & 100FP 20%). Sintering and compaction, in addition, stabilized the system and controlled the initial burst release of the drug. Extended release (ER) Atenolol is an effective alternative of IR tablets in controlling hypertension and treating other cardiovascular diseases.

Keyphrases

cardiovascular disease
blood pressure
fatty acid
emergency department
high frequency
adverse drug
metabolic syndrome
coronary artery disease
drug induced
electronic health record