The snacking rat as model of human obesity: effects of a free-choice high-fat high-sugar diet on meal patterns.

Susanne E la FleurM C M LuijendijkE M van der ZwaalM A D BransR A H Adan

Published in: International journal of obesity (2005) (2013)

We hereby show the importance of choice in the observation of fcHFHS diet-induced hyperphagia, which results in increases in meal number due to sugar drinking without any compensatory decrease in meal size. We thus provide a novel dietary model in rats that mimics important features of human overconsumption that have been ignored in rodent models of obesity.

Keyphrases

endothelial cells
weight loss
insulin resistance
metabolic syndrome
type diabetes
induced pluripotent stem cells
weight gain
pluripotent stem cells
high fat diet induced
physical activity
oxidative stress