A novel mouse model of obstructive sleep apnea by bulking agent-induced tongue enlargement results in left ventricular contractile dysfunction.
Simon LebekPhilipp HegnerChristian SchachKathrin ReuthnerMaria TafelmeierLars Siegfried MaierMichael ArztStefan WagnerPublished in: PloS one (2020)
We describe here the first mouse model of spontaneous inspiratory flow limitations, obstructive apneas, and hypoxia by tongue enlargement due to PTFE injection. These mice develop systolic and diastolic dysfunction and increased CaMKII expression. This mouse model offers great opportunities to investigate the effects of obstructive apneas.
Keyphrases
- mouse model
- left ventricular
- obstructive sleep apnea
- blood pressure
- heart failure
- hypertrophic cardiomyopathy
- oxidative stress
- cardiac resynchronization therapy
- poor prognosis
- acute myocardial infarction
- mitral valve
- high glucose
- diabetic rats
- type diabetes
- positive airway pressure
- atrial fibrillation
- high fat diet induced
- insulin resistance
- wild type
- aortic valve
- sleep apnea
- catheter ablation