The oncometabolite R-2-hydroxyglutarate dysregulates the differentiation of human mesenchymal stromal cells via inducing DNA hypermethylation.

Lizhen LiuKaimin HuJingjing FengHuafang WangShan FuBinsheng WangLimengmeng WangYulin XuXiaohong YuHe Huang

Published in: BMC cancer (2021)

The oncometabolite R-2HG dysregulated the chondrogenic and osteogenic differentiation of MSCs possibly via induction of DNA hypermethylation, improving the role of R-2HG in cartilaginous tumor development.

Keyphrases

circulating tumor
mesenchymal stem cells
cell free
single molecule
endothelial cells
fluorescent probe
bone marrow
living cells
induced pluripotent stem cells
nucleic acid
umbilical cord
pluripotent stem cells
circulating tumor cells