Immunotherapy Plus Chemotherapy Versus Chemotherapy Alone as First-Line Treatment for Advanced Urothelial Cancer: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Isadora MamedeLorena Escalante-RomeroDavi S Gonçalves CelsoPedro C Abrahao ReisMaria Inez DacoregioAna Caroline AlvesCarlos SteccaPublished in: Clinical genitourinary cancer (2024)
In this meta-analysis of RCTs, ICI plus CTX demonstrated a significant association with improved survival at the expense of an increased risk of immune-related adverse events. Therefore, our findings suggest that this combination should be considered as an initial treatment for aUC in platinum-eligible patients who cannot receive EV-P.