Phospholipase PLCE1 Promotes Transcription and Phosphorylation of MCM7 to Drive Tumor Progression in Esophageal Cancer.

Qi Shi Guixuan Xu Yuliang Jiang Baorui Liu Xueping Han Chunfang Zhang Ya Li Zhiyu Zhang Kaige Wang Hao Peng Fangfang Chen Yandi Ma Linyue Zhao Yunzhao Chen Dawei Wu Lan Yang Xingyuan Jia Tao Wen Zhao-Hui Tong Xiaobin Cui Feng Li

Published in: Cancer research (2024)

PLCE1 promotes tumor progression in ESCC by activating PKCα-mediated phosphorylation of E2F1 to upregulate MCM7 and miR-106b-5p expression and by potentiating MCM7 phosphorylation by RIOK2.

Keyphrases

poor prognosis
protein kinase
long non coding rna
signaling pathway
transcription factor
binding protein